Hydrogen (H2) inhibits isoproterenol-induced cardiac hypertrophy via antioxidative pathways

Hydrogen (H2) inhibits isoproterenol-induced cardiac hypertrophy via antioxidative pathways

Background & Purpose: Hydrogen (H2) has been shown to have a strong antioxidant effect on preventing oxidative stress-related diseases. The goal of the present study is to determine the pharmacodynamics of H2 in a model of isoproterenol (ISO)-induced cardiac hypertrophy.Methods: Mice (C57BL/6J;...

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Bibliographic Details
Main Authors: Yaxing Zhang, Jingting Xu, Zhiyuan Long, Chen Wang, Ling Wang, Peng Sun, Ping Li, Tinghuai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Pharmacology
Subjects:
Hydrogen
NADPH Oxidase
Reactive Oxygen Species
cardiac hypertrophy
MAPK
β-adrenoceptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00392/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00392/full

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