iStable 2.0: Predicting protein thermal stability changes by integrating various characteristic modules

Protein mutations can lead to structural changes that affect protein function and result in disease occurrence. In protein engineering, drug design or and optimization industries, mutations are often used to improve protein stability or to change protein properties while maintaining stability. To pr...

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Bibliographic Details
Main Authors: Chi-Wei Chen, Meng-Han Lin, Chi-Chou Liao, Hsung-Pin Chang, Yen-Wei Chu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019304507