The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be realized. Several clinical trials have highlighted the vital...

Full description

Bibliographic Details
Main Authors:	Sandra S. Hammer, Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A. Lydic, Goldis Malek, Daniel R. Saban, Xiaoxin X. Wang, Sugata Hazra, Moshe Levi, Julia V. Busik, Maria B. Grant
Format:	Article
Language:	English
Published:	Elsevier 2017-08-01
Series:	EBioMedicine
Subjects:	Diabetic retinopathy Dyslipidemia Liver X receptor SIRT1 Glucose Retinal inflammation Bone marrow Circulating angiogenic cells Tumor necrosis factor alpha Cholesterol metabolism Reverse cholesterol transport Cholesterol efflux Retinal endothelial cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396417302803

Similar Items

Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions, Cholesterol and the journey of extracellular vesicles
by: Frank W. Pfrieger, et al.
Published: (2018-12-01)

Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein
by: Dmitri Sviridov, et al.
Published: (2000-11-01)

Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux
by: Patricia G. Yancey, et al.
Published: (2001-03-01)

Substrate Stiffness Regulates Cholesterol Efflux in Smooth Muscle Cells
by: Xiuli Mao, et al.
Published: (2021-05-01)

ABCA1: the gatekeeper for eliminating excess tissue cholesterol
by: John F. Oram, et al.
Published: (2001-08-01)

Dietary Betaine Addition Promotes Hepatic Cholesterol Synthesis, Bile Acid Conversion, and Export in Rats
by: Sisi Li, et al.
Published: (2020-05-01)

Sterol Metabolism and Transport in Atherosclerosis and Cancer
by: Yoshio Yamauchi, et al.
Published: (2018-09-01)

Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction[S]
by: Francesca Zimetti, et al.
Published: (2017-10-01)

Importance of macrophage cholesterol content on the flux of cholesterol mass
by: Sandhya Sankaranarayanan, et al.
Published: (2010-11-01)

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux
by: Carlos L.J. Vrins, et al.
Published: (2009-10-01)

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
by: Cheryl L. Wellington, et al.
Published: (2002-11-01)

Differential rate of cholesterol efflux from the apical and basolateral membranes of MDCK cells
by: A.T. Remaley, et al.
Published: (1998-06-01)

Counterpoint: Flexibilization of Fasting for Laboratory Determination of the Lipid Profile in Brazil: Science or Convenience?
by: Maria Cristina de Oliveira Izar

Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase
by: Shobha Ghosh, et al.
Published: (2003-10-01)

The role of Sirtuins in the study of eye diseases
by: Rong-Bin Liang<sup>*</sup>, et al.
Published: (2020-05-01)

The combined effects of genetic variation in the <it>SIRT1</it> gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study
by: Inamori Tomoko, et al.
Published: (2013-01-01)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
by: Xuchen Hu, et al.
Published: (2019-09-01)

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
by: Se-Jin Jeong, et al.
Published: (2017-03-01)

Alcohol consumption stimulates early steps in reverse cholesterol transport
by: M.S. van der Gaag, et al.
Published: (2001-12-01)

The role of nutraceuticals in the treatment of primary dyslipidemia
by: Elias Sanidas, et al.
Published: (2020-01-01)

Knowns and unknowns in the care of pediatric familial hypercholesterolemia
by: Andrew C. Martin, et al.
Published: (2017-09-01)

Regulation of cholesterol distribution in macrophage-derived foam cells by interferon-γ
by: Constantinos G. Panousis, et al.
Published: (2000-01-01)

Sesamin Enhances Cholesterol Efflux in RAW264.7 Macrophages
by: Nan Liu, et al.
Published: (2014-06-01)

Comparison of the capacity of β-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins
by: Aimee E. Christian, et al.
Published: (1999-08-01)

Lower than average HDL cholesterol efflux capacity in Lithuanian population
by: Sandra Kutkiene, et al.
Published: (2019-10-01)

Cellular Localization and Trafficking of the Human ABCG1 Transporter
by: Edward B. Neufeld, et al.
Published: (2014-11-01)

The Human ABCG1 Transporter Mobilizes Plasma Membrane and Late Endosomal Non-Sphingomyelin-Associated-Cholesterol for Efflux and Esterification
by: Edward B. Neufeld, et al.
Published: (2014-12-01)

6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells
by: Xiao Li, et al.
Published: (2018-02-01)

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase
by: Miriam Lee-Rueckert, et al.
Published: (2008-02-01)

Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits
by: Lee A. Morehouse, et al.
Published: (2007-07-01)

Periodontitis decreases the antiatherogenic potency of high density lipoprotein
by: Pirkko J. Pussinen, et al.
Published: (2004-01-01)

Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux
by: Brian K. Nordskog, et al.
Published: (1999-10-01)

Non-high density lipoprotein cholesterol versus low density lipoprotein cholesterol as a discriminating factor for myocardial infarction
by: Sigdel Manoj, et al.
Published: (2012-11-01)

Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing
by: Michel Farnier
Published: (2008-10-01)

High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis
by: Vasily A. Kudinov, et al.
Published: (2021-09-01)

Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease[S]
by: Ana Reis, et al.
Published: (2015-02-01)

Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice
by: Paula R. Pinto, et al.
Published: (2018-05-01)

Apoprotein E and Reverse Cholesterol Transport
by: Godfrey S. Getz, et al.
Published: (2018-11-01)

Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally
by: Baljinder S. Dhaliwal, et al.
Published: (2000-10-01)

Effects of Saponin from Trigonella Foenum-Graecum Seeds on Dyslipidemia
by: Zhi Chen, et al.
Published: (2017-11-01)