The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be realized. Several clinical trials have highlighted the vital...

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Bibliographic Details
Main Authors: Sandra S. Hammer, Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A. Lydic, Goldis Malek, Daniel R. Saban, Xiaoxin X. Wang, Sugata Hazra, Moshe Levi, Julia V. Busik, Maria B. Grant
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:EBioMedicine
Subjects:
Diabetic retinopathy
Dyslipidemia
Liver X receptor
SIRT1
Glucose
Retinal inflammation
Bone marrow
Circulating angiogenic cells
Tumor necrosis factor alpha
Cholesterol metabolism
Reverse cholesterol transport
Cholesterol efflux
Retinal endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302803

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http://www.sciencedirect.com/science/article/pii/S2352396417302803

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