Anti-PrP Mab 6D11 suppresses PrPSc replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo

Anti-PrP Mab 6D11 suppresses PrPSc replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo

The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrPC) into a toxic, infectious, and self-replicating conformer termed PrPSc. Following extracerebral inoculation, the replication of PrPSc is confined for months to years to the lymporeticular s...

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Bibliographic Details
Main Authors: Martin J. Sadowski, Joanna Pankiewicz, Frances Prelli, Henrieta Scholtzova, Daryl S. Spinner, Regina B. Kascsak, Richard J. Kascsak, Thomas Wisniewski
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Neurobiology of Disease
Subjects:
Monoclonal antibodies
Scrapie
Neuroinvasion
Prion
Treatment
Creutzfeldt–Jakob disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900014X

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http://www.sciencedirect.com/science/article/pii/S096999610900014X

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