Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer

Abstract Background The heterogeneity of the breast tumor microenvironment (TME) may contribute to the lack of durable responses to immune checkpoint blockade (ICB); however, mouse models to test this are currently lacking. Proper selection and use of preclinical models are necessary for rigorous, p...

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Bibliographic Details
Main Authors: Jessica Castrillon Lal, Madeline G. Townsend, Anita K. Mehta, Madisson Oliwa, Eric Miller, Alaba Sotayo, Emily Cheney, Elizabeth A. Mittendorf, Anthony Letai, Jennifer L. Guerriero
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Immunotherapy
Immune checkpoint blockade
Syngeneic tumor models
Preclinical mouse models
Jessica Castrillon Lal and Madeline G. Townsend contributed equally to this work
Online Access:https://doi.org/10.1186/s13058-021-01448-1

Internet

https://doi.org/10.1186/s13058-021-01448-1

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