PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology

PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology

Loss of dopamine neurons in experimental parkinsonism results in altered cyclic nucleotide cAMP and cGMP levels throughout the basal ganglia. Our objective was to examine whether expression of phosphodiesterase 10A (PDE10A), an isozyme presenting a unique distribution in basal ganglia, is altered af...

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Bibliographic Details
Main Authors: M. Giorgi, G. Melchiorri, V. Nuccetelli, V. D'Angelo, A. Martorana, R. Sorge, V. Castelli, G. Bernardi, G. Sancesario
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neurobiology of Disease
Subjects:
A2A receptors
Basal ganglia
Caudate–putamen
cGMP
Globus pallidus
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001239

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http://www.sciencedirect.com/science/article/pii/S0969996111001239

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