Relevance of long-lived CD8+ T effector memory (TEM) cells for protective immunity elicited by heterologous prime-boost vaccination.

Relevance of long-lived CD8+ T effector memory (TEM) cells for protective immunity elicited by heterologous prime-boost vaccination.

Owing to the importance of major histocompatibility complex class Ia–restricted CD8+ T cells for host survival following viral, bacterial, fungal, or parasitic infection, it has become largely accepted that these cells should be considered in the design of a new generation of vaccines. For the past...

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Bibliographic Details
Main Authors: José Ronnie Vasconcelos, Mariana Ribeiro Dominguez, Adriano eAraújo, Jonatan eErsching, Cibele Aparecida Tararam, Oscar eBruna-Romero, Mauricio Martins Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Immunology
Subjects:
CD8-Positive T-Lymphocytes
Memory, Long-Term
Vaccines
Viruses
effector function
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00358/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00358/full

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