Gintonin-mediated release of astrocytic vascular endothelial growth factor protects cortical astrocytes from hypoxia-induced cell damages

Background: Gintonin is a ginseng-derived exogenous ligand of the G protein-coupled lysophosphatidic acid (LPA) receptor. We previously reported that gintonin stimulates gliotransmitter release in primary cortical astrocytes. Astrocytes play key roles in the functions of neurovascular systems. Altho...

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Main Authors: Sun-Hye Choi, Hyeon-Joong Kim, Hee-Jung Cho, Sang-Deuk Park, Na-Eun Lee, Sung-Hee Hwang, Hyewon Rhim, Hyoung-Chun Kim, Ik-Hyun Cho, Seung-Yeol Nah
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Ginseng Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845318301362