Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants

Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants

Abstract Background Formic acid is an inhibitory compound present in lignocellulosic hydrolysates. Understanding the complex molecular mechanisms underlying Saccharomyces cerevisiae tolerance to this weak acid at the system level is instrumental to guide synthetic pathway engineering for robustness...

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Bibliographic Details
Main Authors: Sílvia F. Henriques, Nuno P. Mira, Isabel Sá-Correia
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Biotechnology for Biofuels
Subjects:
Formic acid tolerance
Formic acid toxicity
Chemogenomic analysis
Trk1
Haa1
Lignocellulosic hydrolysates
Online Access:http://link.springer.com/article/10.1186/s13068-017-0781-5

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http://link.springer.com/article/10.1186/s13068-017-0781-5

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