Novel cysteine-centered sulfur metabolic pathway in the thermotolerant methylotrophic yeast Hansenula polymorpha.

In yeast and filamentous fungi, sulfide can be condensed either with O-acetylhomoserine to generate homocysteine, the precursor of methionine, or with O-acetylserine to directly generate cysteine. The resulting homocysteine and cysteine can be interconverted through transsulfuration pathway. Here, w...

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Bibliographic Details
Main Authors: Min Jeong Sohn, Su Jin Yoo, Doo-Byoung Oh, Ohsuk Kwon, Sang Yup Lee, Andriy A Sibirny, Hyun Ah Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069077?pdf=render