Single nucleotide polymorphism (SNP)-based loss of heterozygosity (LOH) testing by real time PCR in patients suspect of myeloproliferative disease.

Single nucleotide polymorphism (SNP)-based loss of heterozygosity (LOH) testing by real time PCR in patients suspect of myeloproliferative disease.

During tumor development, loss of heterozygosity (LOH) often occurs. When LOH is preceded by an oncogene activating mutation, the mutant allele may be further potentiated if the wild-type allele is lost or inactivated. In myeloproliferative neoplasms (MPN) somatic acquisition of JAK2V617F may be fol...

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Bibliographic Details
Main Authors: Cornelis J J Huijsmans, Jeroen Poodt, Jan Damen, Johannes C van der Linden, Paul H M Savelkoul, Johannes F M Pruijt, Mirrian Hilbink, Mirjam H A Hermans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3388082?pdf=render

Internet

http://europepmc.org/articles/PMC3388082?pdf=render

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