One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.

One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.

Several polymorphic gene variants within one-carbon metabolism, an essential pathway for nucleotide synthesis and methylation reactions, are related to cancer risk. An aberrant DNA methylation is a common feature in cancer but whether the link between one-carbon metabolism variants and cancer occurs...

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Bibliographic Details
Main Authors: Sara Moruzzi, Patrizia Guarini, Silvia Udali, Andrea Ruzzenente, Alfredo Guglielmi, Simone Conci, Patrizia Pattini, Nicola Martinelli, Oliviero Olivieri, Stephanie A Tammen, Sang-Woon Choi, Simonetta Friso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5624642?pdf=render

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http://europepmc.org/articles/PMC5624642?pdf=render

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