Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we considered if sphingomyelinase is relevant t...

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Bibliographic Details
Main Authors: Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
PIEZO1
inactivation
endothelium
sphingomyelinase
SMPD3
ceramide
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312146

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http://www.sciencedirect.com/science/article/pii/S2211124720312146

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