The tumor microenvironment and radiotherapy response; a central role for cancer-associated fibroblasts

Tumor growth is not only dictated by events involving tumor cells, but also by the environment they reside in, the so-called tumor microenvironment (TME). In the TME, cancer-associated fibroblasts (CAFs) are often the predominant cell type. CAFs were long considered to be of limited importance in th...

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Bibliographic Details
Main Authors: Marleen Ansems, Paul N. Span
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Clinical and Translational Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630820300264