The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer—The Impact in Intratumoral Heterogeneity

The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer—The Impact in Intratumoral Heterogeneity

Purpose: Intratumoral genetic heterogeneity (ITGH) is a common feature of solid tumors. However, little is known about the effect of neoadjuvant chemoradiation (nCRT) in ITGH of rectal tumors that exhibit poor response to nCRT. Here, we examined the impact of nCRT in the mutational profile and ITGH...

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Bibliographic Details
Main Authors: Fabiana Bettoni, Cibele Masotti, Bruna R. Corrêa, Elisa Donnard, Filipe F. dos Santos, Guilherme P. São Julião, Bruna B. Vailati, Angelita Habr-Gama, Pedro A. F. Galante, Rodrigo O. Perez, Anamaria A. Camargo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
neoadjuvant therapy
rectal cancer
intratumoral heterogeneity
clonal evolution
therapy resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00974/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00974/full

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