Paired Rheumatoid Arthritis Synovial Biopsies From Small and Large Joints Show Similar Global Transcriptomic Patterns With Enrichment of Private Specificity TCRB and TCR Signaling Pathways

Paired Rheumatoid Arthritis Synovial Biopsies From Small and Large Joints Show Similar Global Transcriptomic Patterns With Enrichment of Private Specificity TCRB and TCR Signaling Pathways

ObjectivesWe explored histological and transcriptomic profiles of paired synovial biopsies from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at the individual level.MethodsSynovial biopsies were performed simultaneously in one small and one large joint per pa...

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Bibliographic Details
Main Authors: Clement Triaille, Louise Vansteenkiste, Manuel Constant, Jérôme Ambroise, Laurent Méric de Bellefon, Adrien Nzeusseu Toukap, Tatiana Sokolova, Christine Galant, Pierre Coulie, Javier Carrasco, Patrick Durez, Bernard R. Lauwerys
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
synovial biopsy
gene expression
T lymphocytes
TCR repertoire
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.593083/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.593083/full

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