E3 ligase carboxyl-terminus of Hsp70-interacting protein (CHIP) suppresses fibrotic properties in oral mucosa

Background/purpose: Oral submucous fibrosis (OSF) represents a precancerous lesion of oral mucosa that may progress into oral cancer and its major etiological factor is areca nut chewing. Carboxyl-terminus of Hsp70-interacting protein (CHIP) functions as an ubiquitin E3 ligase and is associated with...

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Bibliographic Details
Main Authors: Shiuan-Chih Chen, Chia-Ming Liu, Pei-Ling Hsieh, Yi-Wen Liao, Yi-Mei Joy Lin, Cheng-Chia Yu, Chuan-Hang Yu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Journal of the Formosan Medical Association
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664619306084