HIF-1α Provokes Delayed Neutrophil Apoptosis by Decreasing 24P3 Expression and Intracellular Iron Content

Neutrophil apoptosis is delayed in medical conditions associated to anoxia or hypoxia, prolonging tissue destruction and fostering the inflammation. Hypoxia Inducible Factor-1α (HIF-1α), is a main regulator of delayed neutrophil apoptosis but the mechanism of action is poorly characterized. Neutroph...

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Bibliographic Details
Main Authors: A. Pérez-Ladaga, M.A. Muñoz, C. Mastora, A. Sola
Format: Article
Language:English
Published: SAGE Publishing 2014-01-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X1401200106