Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies

While phospholipidosis is thought to be an adaptive response to chemical challenge, many phospholipogenic compounds are known to display adverse effects in preclinical species and humans. To investigate the link between phospholipogenic administration and incidence of preclinical histological signal...

Full description

Bibliographic Details
Main Authors: Linda R. Barone, Scott Boyer, James R. Damewood, James Fikes, Paul J. Ciaccio
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2012/308594