Irinotecan (CPT-11) Canonical Anti-Cancer Drug Can also Modulate Antiviral and Pro-Inflammatory Responses of Primary Human Synovial Fibroblasts

Irinotecan (CPT-11) Canonical Anti-Cancer Drug Can also Modulate Antiviral and Pro-Inflammatory Responses of Primary Human Synovial Fibroblasts

Alphaviruses are a group of arboviruses that generate chronic inflammatory rheumatisms in humans. Currently, no approved vaccines or antiviral therapies are available to prevent or treat alphavirus-induced diseases. The aim of this study was to evaluate the repositioning of the anti-cancer molecule...

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Bibliographic Details
Main Authors: Anthony Dobi, Philippe Gasque, Pascale Guiraud, Jimmy Selambarom
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
irinotecan
arthritis
alphavirus infection
human synovial fibroblasts
antiviral response
pro-inflammatory response
Online Access:https://www.mdpi.com/2073-4409/10/6/1431

Internet

https://www.mdpi.com/2073-4409/10/6/1431

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