PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages

PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages

NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted to monocytic lineages such as monocytes, macrophage...

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Bibliographic Details
Main Authors: Takuya Yashiro, Machiko Yamamoto, Sanae Araumi, Mutsuko Hara, Kyoko Yogo, Koichiro Uchida, Kazumi Kasakura, Chiharu Nishiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
N LRP3
inflammasome
PU.1
IRF8
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649572/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.649572/full

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