Tumor- and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis

Abstract Chemotherapeutic drugs frequently encounter multidrug resistance. ATP from mitochondria helps overexpression of drug efflux pumps to induce multidrug resistance, so mitochondrial delivery as a means of “repurposing’’ chemotherapeutic drugs currently used in the clinic appears to be a worthw...

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Bibliographic Details
Main Authors: He Wang, Fangke Zhang, Huaying Wen, Wenwen Shi, Qiudi Huang, Yugang Huang, Jiacui Xie, Peiyin Li, Jianhai Chen, Linghao Qin, Yi Zhou
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Nanobiotechnology
Subjects:
Online Access:https://doi.org/10.1186/s12951-019-0562-3