Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.

Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.

Nibrin (also named NBN or NBS1) is a component of the MRE11/RAD50/NBN complex, which is involved in early steps of DNA double strand breaks sensing and repair. Mutations within the NBN gene are responsible for the Nijmegen breakage syndrome (NBS). The 90% of NBS patients are homozygous for the 657de...

Full description

Bibliographic Details
Main Authors: Domenica Cilli, Cristiana Mirasole, Rosa Pennisi, Valeria Pallotta, Angelo D'Alessandro, Antonio Antoccia, Lello Zolla, Paolo Ascenzi, Alessandra di Masi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4259352?pdf=render

Internet

http://europepmc.org/articles/PMC4259352?pdf=render

Similar Items