GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype

GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype

Macrophages are critical for regulation of inflammatory response during endotoxemia and septic shock. However, the mediators underlying their regulatory function remain obscure. Growth differentiation factor 3 (GDF3), a member of transforming growth factor beta (TGF-β) superfamily, has been...

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Bibliographic Details
Main Authors: Lu Wang, Yutian Li, Xiaohong Wang, Peng Wang, Kobina Essandoh, Shunan Cui, Wei Huang, Xingjiang Mu, Zhenling Liu, Yigang Wang, Tianqing Peng, Guo-Chang Fan
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
growth differentiation factor 3
endotoxin
cardiac dysfunction
cardiac inflammation
smad
macrophage polarization
nlrp3
sepsis biomarker
Online Access:https://www.mdpi.com/2073-4409/9/1/120

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https://www.mdpi.com/2073-4409/9/1/120

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