Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

Recently, we and others have illustrated that extracellular vesicles (EVs) have the potential to support hematopoietic stem and progenitor cell (HSPC) expansion; however, the mechanism and processes responsible for the intercellular communication by EVs are still unknown. In the current study, we in...

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Bibliographic Details
Main Authors: Corina A. Ghebes, Jess Morhayim, Marion Kleijer, Merve Koroglu, Stefan J. Erkeland, Remco Hoogenboezem, Eric Bindels, Floris P. J. van Alphen, Maartje van den Biggelaar, Martijn A. Nolte, Bram C. J. van der Eerden, Eric Braakman, Carlijn Voermans, Jeroen van de Peppel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
extracellular vesicles
BMSCs
HSPC expansion
transplantation
hematopoietic niche
intercellular communication
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.640419/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2021.640419/full

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