Recombinant NAD-dependent SIR-2 protein of Leishmania donovani: immunobiochemical characterization as a potential vaccine against visceral leishmaniasis.

BACKGROUND: The development of a vaccine conferring long-lasting immunity remains a challenge against visceral leishmaniasis (VL). Immunoproteomic characterization of Leishmania donovani proteins led to the identification of a novel protein NAD+-dependent Silent Information regulatory-2 (SIR2 family...

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Bibliographic Details
Main Authors: Rajendra K Baharia, Rati Tandon, Tanuj Sharma, Manish K Suthar, Sanchita Das, Mohammad Imran Siddiqi, Jitendra Kumar Saxena, Shaym Sundar, Anuradha Dube
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4351947?pdf=render