Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo

Metformin Enhances Nomegestrol Acetate Suppressing Growth of Endometrial Cancer Cells and May Correlate to Downregulating mTOR Activity In Vitro and In Vivo

This study investigated the effect of a novel progestin and its combination with metformin on the growth of endometrial cancer (EC) cells. Inhibitory effects of four progestins, including nomegestrol acetate (NOMAC), medroxyprogesterone acetate, levonorgestrel, and cyproterone acetate, were evaluate...

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Bibliographic Details
Main Authors: Can Cao, Jie-yun Zhou, Shu-wu Xie, Xiang-jie Guo, Guo-ting Li, Yi-juan Gong, Wen-jie Yang, Zhao Li, Rui-hua Zhong, Hai-hao Shao, Yan Zhu
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
progestins
nomegestrol acetate
metformin
endometrial cancer
apoptosis
mTOR signaling
Online Access:https://www.mdpi.com/1422-0067/20/13/3308

Internet

https://www.mdpi.com/1422-0067/20/13/3308

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