Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients

Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients

The aim of the research was to investigate the pharmacokinetics (PK) of enteric-coated mycophenolate sodium (EC-MPS) by quantification of the active metabolite of mycophenolic acid (MPA) after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney...

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Bibliographic Details
Main Authors: Jun Zhang, Mengmeng Jia, Lihua Zuo, Na Li, Yonggang Luo, Zhi Sun, Xiaojian Zhang, Zhenfeng Zhu
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Enteric-coated
Mycophenolate sodium
Mycophenolic acid
Nonlinear dynamics
Kidney transplantation
Pharmacokinetics
UPLC-UV
Human plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516302544

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http://www.sciencedirect.com/science/article/pii/S2211383516302544

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