Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment.

Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment.

Environmental enrichment produces protective addiction and depression phenotypes in rats. ΔFosB is a transcription factor that regulates reward in the brain and is induced by psychological stress as well as drugs of abuse. However, the role played by ΔFosB in the protective phenotypes of environment...

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Bibliographic Details
Main Authors: Yafang eZhang, Elizabeth J. Crofton, Dingge eLi, Mary Kay eLobo, Xiuzhen eFan, Eric J Nestler, Thomas A Green
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Depression
environmental enrichment
overexpression
adeno-associated virus (AAV)
cocaine self administration
ΔFosB
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00297/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00297/full

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