Generation of in situ sequencing based OncoMaps to spatially resolve gene expression profiles of diagnostic and prognostic markers in breast cancerResearch in Context

Background: Gene expression analysis of breast cancer largely relies on homogenized tissue samples. Due to the high degree of cellular and molecular heterogeneity of tumor tissues, bulk tissue-based analytical approaches can only provide very limited system-level information about different signalin...

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Bibliographic Details
Main Authors: Jessica Svedlund, Carina Strell, Xiaoyan Qian, Kilian J.C. Zilkens, Nicholas P. Tobin, Jonas Bergh, Anieta M. Sieuwerts, Mats Nilsson
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419306073