Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice

Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice

Targeting antigen to surface receptors on dendritic cells (DCs) can improve antibody response against subunit vaccines. We have previously observed that human XCL1-fusion vaccines target murine Xcr1+ DCs without actively inducing endocytosis of the antigen, resulting in enhanced antibody responses i...

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Bibliographic Details
Main Authors: Arnar Gudjonsson, Tor Kristian Andersen, Vibeke Sundvold-Gjerstad, Bjarne Bogen, Even Fossum
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
targeting
Xcl1
cDC1 dendritic cells
vaccine
DNA vaccine
antibody response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01086/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01086/full

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