Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes

Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes

Binge drinking is a dangerous pattern of behavior. We tested whether chronically manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)) could produce lasting effects on ethanol binge-like drinking in mice se...

Full description

Bibliographic Details
Main Authors:	Dar’ya Y. Pozhidayeva, Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, Angela R. Ozburn
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Brain Sciences
Subjects:	binge drinking genes signaling pathways dreadds or chemogenetics high drinking in the dark mice
Online Access:	https://www.mdpi.com/2076-3425/10/2/109

Similar Items

Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats
by: Mia Haaranen, et al.
Published: (2020-11-01)

Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice
by: John C. Crabbe, et al.
Published: (2020-04-01)

Binge Eating, But Not Other Disordered Eating Symptoms, Is a Significant Contributor of Binge Drinking Severity: Findings from a Cross-Sectional Study among French Students
by: Benjamin Rolland, et al.
Published: (2017-10-01)

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum
by: Patrick Aldrin-Kirk, et al.
Published: (2018-01-01)

Increased Nucleus Accumbens Volume in College Binge Drinkers - Preliminary Evidence From Manually Segmented MRI Analysis
by: Sónia S. Sousa, et al.
Published: (2020-02-01)

Determining the Impact of Repeated Binge Drinking on Corticostriatal Theta Synchrony
by: Ardinger, Cherish
Published: (2021)

“I cannot stand the boredom.” Binge drinking expectancies in adolescence
by: Roberta Biolcati, et al.
Published: (2016-06-01)

La personnalité et le fonctionnement cognitif comme facteurs de vulnérabilité au binge drinking chez des étudiants : rôle des attentes, des motivations à consommer et du genre dans cette relation
by: Wever, Élodie de
Published: (2015)

An Intersectional Approach to Target Neural Circuits With Cell- and Projection-Type Specificity: Validation in the Mesolimbic Dopamine System
by: Nefeli Kakava-Georgiadou, et al.
Published: (2019-02-01)

Binge drinking: a pattern associated with a risk of problems of alcohol use among university students
by: André Bedendo, et al.
Published: (2017-09-01)

Eye-Drops for Activation of DREADDs
by: William T. Keenan, et al.
Published: (2017-11-01)

The association between at-risk gambling and binge drinking in the general Swedish population
by: Kristina Sundqvist, et al.
Published: (2015-12-01)

Adolescent mice are resilient to alcohol withdrawal-induced anxiety and changes in indices of glutamate function within the nucleus accumbens
by: Kaziya M Lee, et al.
Published: (2016-11-01)

Stability of a binge drinking model with delay
by: Hai-Feng Huo, et al.
Published: (2017-01-01)

Correlates of binge drinking among Brazilian adolescents
by: Juliana Gabrielle Martins-Oliveira, et al.

Religiosidade como possível fator de proteção do “binge drinking” por escolares de 12 anos de idade: um estudo de base populacional
by: Mariana Oliveira Guimarães, et al.

Statistical analysis of a survey about diffusion of binge drinking and drunkorexia among students in Palermo
by: Fabio Venturella, et al.
Published: (2018-07-01)

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk
by: Cindy L. Ehlers, et al.
Published: (2020-10-01)

Understanding the Influence of Eating Patterns on Binge Drinking: A Mediation Model
by: Tamara Escrivá-Martínez, et al.
Published: (2020-12-01)

Social, economic and family factors associated with binge drinking in Spanish adolescents
by: Ana Magdalena Vargas-Martínez, et al.
Published: (2020-04-01)

Personality Traits Related to Binge Drinking: A Systematic Review
by: Ana Adan, et al.
Published: (2017-07-01)

Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1
by: Yana Van Den Herrewegen, et al.
Published: (2021-09-01)

The Burden of Binge and Heavy Drinking on the Brain: Effects on Adolescent and Young Adult Neural Structure and Function
by: Anita Cservenka, et al.
Published: (2017-06-01)

Internet use and adolescent binge drinking: Findings from the Monitoring the Future study
by: Karen J. Mu, et al.
Published: (2015-12-01)

Editorial: Binge Drinking in the Adolescent and Young Brain
by: Eduardo López-Caneda, et al.
Published: (2019-01-01)

Accumbens coordinated reset stimulation in mice exhibits ameliorating aftereffects on binge alcohol drinking
by: Allen L. Ho, et al.
Published: (2021-03-01)

Fatores associados ao binge drinking, beber frequente ou pesado e primeiro uso de álcool entre adolescentes brasileiros
by: Conegundes, Lara Silvia Oliveira [UNIFESP]
Published: (2018)

Protocol for a systematic review of the factors associated with binge drinking among adolescents and young adults
by: Jennifer Hasselgård-Rowe, et al.
Published: (2017-04-01)

Binge Drinking Effects on EEG in Young Adult Humans
by: Kelly E. Courtney, et al.
Published: (2010-05-01)

Age at first alcohol use predicts current alcohol use, binge drinking and mixing of alcohol with energy drinks among Ontario Grade 12 students in the COMPASS study
by: Simone D. Holligan, et al.
Published: (2019-11-01)

Binge Drinking and Risk of Breast Cancer: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project
by: Rodrigo Sánchez-Bayona, et al.
Published: (2020-03-01)

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice
by: Kaziya M. Lee, et al.
Published: (2018-11-01)

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice
by: Macarena González-Portilla, et al.
Published: (2021-05-01)

Revision of AUDIT Consumption Items to Improve the Screening of Youth Binge Drinking
by: María-Teresa Cortés-Tomás, et al.
Published: (2017-06-01)

Binge drinking in relation to services – bibliometric analysis of scientific research directions
by: Glińska Ewa, et al.
Published: (2018-03-01)

The role of negative urgency in risky alcohol drinking and binge-eating in United Kingdom male and female students
by: Christina Ralph-Nearman, et al.
Published: (2020-06-01)

Trust Me, You've had ENOUGH: The use of differential relationships to decrease the likelihood of binge drinking in different contexts
by: Pratt, Sarah Joy
Published: (2014)

Neural and cognitive biomarkers of binge and heavy drinking
by: Maksimovskiy, Arkadiy L.
Published: (2017)

Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention
by: Allyson L. Dir, et al.
Published: (2017-12-01)

Prevalence of binge drinking and associated behaviours among 3286 college students in France
by: Marie-Pierre Tavolacci, et al.
Published: (2016-02-01)