Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes

Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes

Binge drinking is a dangerous pattern of behavior. We tested whether chronically manipulating nucleus accumbens (NAc) activity (via clozapine-N-oxide (CNO) and Designer Receptors Exclusively Activated by Designer Drugs (DREADD)) could produce lasting effects on ethanol binge-like drinking in mice se...

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Bibliographic Details
Main Authors: Dar’ya Y. Pozhidayeva, Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, Angela R. Ozburn
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Brain Sciences
Subjects:
binge drinking
genes
signaling pathways
dreadds or chemogenetics
high drinking in the dark mice
Online Access:https://www.mdpi.com/2076-3425/10/2/109

Internet

https://www.mdpi.com/2076-3425/10/2/109

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