Changes in cortical gene expression in the muscarinic M1 receptor knockout mouse: potential relevance to schizophrenia, Alzheimer’s disease and cognition

Abstract Postmortem and neuroimaging studies show low levels of cortical muscarinic M1 receptors (CHRM1) in patients with schizophrenia which is significant because CHRM signalling has been shown to change levels of gene expression and cortical gene expression is altered in schizophrenia. We decided...

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Bibliographic Details
Main Authors: Brian Dean, Elizabeth Scarr
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:npj Schizophrenia
Online Access:https://doi.org/10.1038/s41537-021-00174-z