Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores

Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores

Protein nanopores are emerging as sensors for a variety of biomolecules. Here the authors develop a nanopore based on the bacterial toxin ClyA, in conjunction with binding proteins for glucose and asparagine, to detect these biomolecules simultaneously from a variety of unprocessed, diluted body flu...

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Main Authors: Nicole Stéphanie Galenkamp, Misha Soskine, Jos Hermans, Carsten Wloka, Giovanni Maglia
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06534-1
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spelling doaj-f5d06fa761e34c8ab22f09254e397e182021-05-11T10:24:55ZengNature Publishing GroupNature Communications2041-17232018-10-01911810.1038/s41467-018-06534-1Direct electrical quantification of glucose and asparagine from bodily fluids using nanoporesNicole Stéphanie Galenkamp0Misha Soskine1Jos Hermans2Carsten Wloka3Giovanni Maglia4Groningen Biomolecular Sciences and Biotechnology Institute, University of GroningenGroningen Biomolecular Sciences and Biotechnology Institute, University of GroningenAnalytical Biochemistry, Department of Pharmacy, University of GroningenGroningen Biomolecular Sciences and Biotechnology Institute, University of GroningenGroningen Biomolecular Sciences and Biotechnology Institute, University of GroningenProtein nanopores are emerging as sensors for a variety of biomolecules. Here the authors develop a nanopore based on the bacterial toxin ClyA, in conjunction with binding proteins for glucose and asparagine, to detect these biomolecules simultaneously from a variety of unprocessed, diluted body fluids.https://doi.org/10.1038/s41467-018-06534-1
collection DOAJ
language English
format Article
sources DOAJ
author Nicole Stéphanie Galenkamp
Misha Soskine
Jos Hermans
Carsten Wloka
Giovanni Maglia
spellingShingle Nicole Stéphanie Galenkamp
Misha Soskine
Jos Hermans
Carsten Wloka
Giovanni Maglia
Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
Nature Communications
author_facet Nicole Stéphanie Galenkamp
Misha Soskine
Jos Hermans
Carsten Wloka
Giovanni Maglia
author_sort Nicole Stéphanie Galenkamp
title Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_short Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_full Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_fullStr Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_full_unstemmed Direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
title_sort direct electrical quantification of glucose and asparagine from bodily fluids using nanopores
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description Protein nanopores are emerging as sensors for a variety of biomolecules. Here the authors develop a nanopore based on the bacterial toxin ClyA, in conjunction with binding proteins for glucose and asparagine, to detect these biomolecules simultaneously from a variety of unprocessed, diluted body fluids.
url https://doi.org/10.1038/s41467-018-06534-1
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AT mishasoskine directelectricalquantificationofglucoseandasparaginefrombodilyfluidsusingnanopores
AT joshermans directelectricalquantificationofglucoseandasparaginefrombodilyfluidsusingnanopores
AT carstenwloka directelectricalquantificationofglucoseandasparaginefrombodilyfluidsusingnanopores
AT giovannimaglia directelectricalquantificationofglucoseandasparaginefrombodilyfluidsusingnanopores
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