VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome.

VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome.

Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disorder, epilepsy, and a growing number of other disord...

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Bibliographic Details
Main Authors: Weixiang Guo, Keita Tsujimura, Maky Otsuka I, Koichiro Irie, Katsuhide Igarashi, Kinichi Nakashima, Xinyu Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4072629?pdf=render

Internet

http://europepmc.org/articles/PMC4072629?pdf=render

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