Measuring Alphavirus Fidelity Using Non-Infectious Virus Particles

Measuring Alphavirus Fidelity Using Non-Infectious Virus Particles

Mutations are incorporated into the genomes of RNA viruses at an optimal frequency and altering this precise frequency has been proposed as a strategy to create live-attenuated vaccines. However, determining the effect of specific mutations that alter fidelity has been difficult because of the rapid...

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Bibliographic Details
Main Authors: Edward I. Patterson, Kamil Khanipov, Daniele M. Swetnam, Samantha Walsdorf, Tiffany F. Kautz, Saravanan Thangamani, Yuriy Fofanov, Naomi L. Forrester
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
Alphavirus
arbovirus
fidelity mutants
mutation frequency
Online Access:https://www.mdpi.com/1999-4915/12/5/546

Internet

https://www.mdpi.com/1999-4915/12/5/546

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