Synthesis and Evaluation of the Antitumor Activity of Novel 1-(4-Substituted phenyl)-2-ethyl Imidazole Apoptosis Inducers In Vitro

Novel imidazole derivatives were designed, prepared, and evaluated in vitro for antitumor activity. The majority of the tested derivatives showed improved antiproliferative activity compared to the positive control drugs 5-FU and MTX. Among them, compound <b>4f</b> exhibited outstanding...

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Bibliographic Details
Main Authors: Zhen-Wang Li, Chun-Yan Zhong, Xiao-Ran Wang, Shi-Nian Li, Chun-Yuan Pan, Xin Wang, Xian-Yu Sun
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
Bax
Online Access:https://www.mdpi.com/1420-3049/25/18/4293