CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes

CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes

Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promo...

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Bibliographic Details
Main Authors: Zachary L. Benet, Matangi Marthi, Fang Ke, Rita Wu, Jackson S. Turner, Jahan B. Gabayre, Michael I. Ivanitskiy, Sahil S. Sethi, Irina L. Grigorova
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
germinal centers
follicular regulatory T cells (Tfr)
CCL3/MIP1-alpha
2-photon imaging
follicular helper T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02044/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02044/full

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