Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models

Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models

Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival. Clonal evolution also occurs when a subset of cells leave the primary tumor to form metastases, which leads to reduced...

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Bibliographic Details
Main Authors: Kathleen Sprouffske, Grainne Kerr, Cheng Li, Anirudh Prahallad, Ramona Rebmann, Verena Waehle, Ulrike Naumann, Hans Bitter, Michael R Jensen, Francesco Hofmann, Saskia M Brachmann, Stéphane Ferretti, Audrey Kauffmann
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Heterogeneity
Clonal evolution
Breast cancer
Metastasis
Patient derived xenograft models
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019302879

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http://www.sciencedirect.com/science/article/pii/S2001037019302879

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