Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

CD38 is the major NAD+-hydrolyzing ecto-enzyme in most mammals. As a type II transmembrane protein, CD38 is also a promising target for the immunotherapy of multiple myeloma (MM). Nanobodies are single immunoglobulin variable domains from heavy chain antibodies that naturally occur in camelids. Usin...

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Bibliographic Details
Main Authors: Natalie Baum, Marie Eggers, Julia Koenigsdorf, Stephan Menzel, Julia Hambach, Tobias Staehler, Ralf Fliegert, Frederike Kulow, Gerhard Adam, Friedrich Haag, Peter Bannas, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
CD38
NAD+
antibody-dependent cellular cytotoxicity
complement-dependent cytotoxicity
multiple myeloma
nanobody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.703574/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.703574/full

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