Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimat...

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Bibliographic Details
Main Authors: Zhen-Biao Zhang, Dan-Dan Luo, Jian-Hui Xie, Yan-Fang Xian, Zheng-Quan Lai, Yu-Hong Liu, Wei-Hai Liu, Jian-Nan Chen, Xiao-Ping Lai, Zhi-Xiu Lin, Zi-Ren Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
tetrahydrocurcumin
octahydrocucumin
curcumin
inflammation
COX-2
TAK1-NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01181/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01181/full

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