How many samples are needed to infer truly clonal mutations from heterogenous tumours?

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

Abstract Background Modern cancer treatment strategies aim to target tumour specific genetic (or epigenetic) alterations. Treatment response improves if these alterations are clonal, i.e. present in all cancer cells within tumours. However, the identification of truly clonal alterations is impaired...

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Bibliographic Details
Main Authors: Luka Opasic, Da Zhou, Benjamin Werner, David Dingli, Arne Traulsen
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
Intratumour heterogeneity
Clonal mutations
Spatial model
Truncal mutations
Targeted therapy
Somatic evolution
Online Access:http://link.springer.com/article/10.1186/s12885-019-5597-1

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http://link.springer.com/article/10.1186/s12885-019-5597-1

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