Selective mechanism of action of dietary peptides from common bean on HCT116 human colorectal cancer cells through loss of mitochondrial membrane potential and DNA damage

Selective mechanism of action of dietary peptides from common bean on HCT116 human colorectal cancer cells through loss of mitochondrial membrane potential and DNA damage

The inhibitory effect of pure peptides from common bean on human colorectal cancer cells, their ability to enhance oxaliplatin effects, and mechanisms of action were evaluated. Peptides GLTSK, LSGNK, GEGSGA, MTEEY, and MPACGSS were tested for cytotoxic effects on HCT116 and CCD-33Co human normal col...

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Bibliographic Details
Main Authors: Diego A. Luna-Vital, Elvira González de Mejía, Guadalupe Loarca-Piña
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Functional Foods
Subjects:
Common bean
Bioactive peptides
Colorectal cancer
Synergistic interaction
Oxaliplatin
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464616000773

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http://www.sciencedirect.com/science/article/pii/S1756464616000773

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