Sex Differences in the Pro-Angiogenic Response of Human Endothelial Cells: Focus on PFKFB3 and FAK Activation

Sex Differences in the Pro-Angiogenic Response of Human Endothelial Cells: Focus on PFKFB3 and FAK Activation

Female hormones and sex-specific factors are established determinants of endothelial function, yet their relative contribution to human endothelium phenotypes has not been defined. Using human umbilical vein endothelial cells (HUVECs) genotyped by donor's sex, we investigated the influence of s...

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Bibliographic Details
Main Authors: Carlotta Boscaro, Annalisa Trenti, Chiara Baggio, Chiara Scapin, Lucia Trevisi, Andrea Cignarella, Chiara Bolego
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
endothelial cells
sex-specific factors
angiogenesis
estrogen
glycolytic enzymes
adhesion molecules
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.587221/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.587221/full

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