Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

Neuronal morphogenesis requires multiple regulatory pathways to appropriately determine axonal and dendritic structures, thereby to enable the functional neural connectivity. Yet, however, the precise mechanisms and components that regulate neuronal morphogenesis are still largely unknown. Here, we...

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Bibliographic Details
Main Authors: Youngsik Woo, Soo Jeong Kim, Bo Kyoung Suh, Yongdo Kwak, Hyun-Jin Jung, Truong Thi My Nhung, Dong Jin Mun, Ji-Ho Hong, Su-Jin Noh, Seunghyun Kim, Ahryoung Lee, Seung Tae Baek, Minh Dang Nguyen, Youngshik Choe, Sang Ki Park
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
NDEL1 phosphorylation
TARA-DYRK2-GSK3β complex
neuronal morphogenesis
axon/dendrite outgrowth
neuronal arborization
filamentous actin dynamics
Online Access:https://elifesciences.org/articles/50850

Internet

https://elifesciences.org/articles/50850

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