SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

SPOP and OTUD7A Control EWS–FLI1 Protein Stability to Govern Ewing Sarcoma Growth

Abstract Chromosomal translocation results in development of an Ewing sarcoma breakpoint region 1‐Friend leukemia integration 1 (EWS–FLI1) fusion oncogene in the majority of Ewing sarcoma. The persistent dependence of the tumor for this oncoprotein points to EWS–FLI1 as an ideal drug target. Althoug...

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Bibliographic Details
Main Authors: Siyuan Su, Jianfeng Chen, Yao Jiang, Ying Wang, Tamara Vital, Jiaming Zhang, Christian Laggner, Kong T. Nguyen, Zhichuan Zhu, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Ian J. Davis, Pengda Liu
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Advanced Science
Subjects:
7Ai
CK1
Ewing sarcoma
EWS–FLI1
OTUD7A
SPOP
Online Access:https://doi.org/10.1002/advs.202004846

Internet

https://doi.org/10.1002/advs.202004846

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