Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias

Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias

Background: The underlying pathology of inguinal hernia is still not fully known; thus, further investigations of genetic backgrounds is needed. Here, we aimed to identify genetic factors attributing to inguinal hernias and explore the polygenic architecture of which some components are population-s...

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Main Authors: Keiko Hikino, M.D., Ph.D, Masaru Koido, Ph.D., Kohei Tomizuka, B.S., Xiaoxi Liu, Ph.D., Yukihide Momozawa, D.V.M., Ph.D., Takayuki Morisaki, M.D., Ph.D., Yoshinori Murakami, M.D., Ph.D., The Biobank Japan Project, Taisei Mushiroda, Ph.D., Chikashi Terao, M.D., Ph.D.
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
inguinal hernia
genome-wide association studies
trans-ethnic meta-analysis
polygenic architecture
BioBank Japan
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642100325X

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http://www.sciencedirect.com/science/article/pii/S235239642100325X

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