Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.

Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.

In this communication, we demonstrate that galectin (Gal)-9 acts to constrain CD8(+) T cell immunity to Herpes Simplex Virus (HSV) infection. In support of this, we show that animals unable to produce Gal-9, because of gene knockout, develop acute and memory responses to HSV that are of greater magn...

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Bibliographic Details
Main Authors: Sharvan Sehrawat, Pradeep B J Reddy, Naveen Rajasagi, Amol Suryawanshi, Mitsuomi Hirashima, Barry T Rouse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2865527?pdf=render

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http://europepmc.org/articles/PMC2865527?pdf=render

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